Siddharthan Chandran: Can the damaged brain repair itself?


I’m very pleased to be here today to talk to you all about how we might repair the damaged brain, and I’m particularly excited by this field, because as a neurologist myself, I believe that this offers one of the great ways that we might be able to offer hope for patients who today live with devastating and yet untreatable diseases of the brain. So here’s the problem. You can see here the picture of somebody’s brain with Alzheimer’s disease next to a healthy brain, and what’s obvious is, in the Alzheimer’s brain, ringed red, there’s obvious
damage — atrophy, scarring. And I could show you equivalent pictures from other disease: multiple sclerosis, motor neuron disease, Parkinson’s disease, even Huntington’s disease, and they would all tell a similar story. And collectively these brain disorders represent one of the major public health threats of our time. And the numbers here are really rather staggering. At any one time, there are 35 million people today living with one of these brain diseases, and the annual cost globally is 700 billion dollars. I mean, just think about that. That’s greater than one percent of the global GDP. And it gets worse, because all these numbers are rising because these are by and large age-related diseases, and we’re living longer. So the question we really need to ask ourselves is, why, given the devastating impact of these diseases to the individual, never mind the scale of the societal problem, why are there no effective treatments? Now in order to consider this, I first need to give you a crash course in how the brain works. So in other words, I need to tell you everything I learned at medical school. (Laughter) But believe me, this isn’t going to take very long. Okay? (Laughter) So the brain is terribly simple: it’s made up of four cells, and two of them are shown here. There’s the nerve cell, and then there’s the myelinating cell, or the insulating cell. It’s called oligodendrocyte. And when these four cells work together in health and harmony, they create an extraordinary
symphony of electrical activity, and it is this electrical activity that underpins our ability to think, to emote, to remember, to learn, move, feel and so on. But equally, each of these individual four cells alone or together, can go rogue or die, and when that happens, you get damage. You get damaged wiring. You get disrupted connections. And that’s evident here with the slower conduction. But ultimately, this damage will manifest as disease, clearly. And if the starting dying nerve cell is a motor nerve, for example, you’ll get motor neuron disease. So I’d like to give you a real-life illustration of what happens with motor neuron disease. So this is a patient of mine called John. John I saw just last week in the clinic. And I’ve asked John to tell us something
about what were his problems that led to the initial diagnosis of motor neuron disease. John: I was diagnosed in October in 2011, and the main problem was a breathing problem, difficulty breathing. Siddharthan Chandran: I don’t know if you
caught all of that, but what John was telling us was that difficulty with breathing led eventually to the diagnosis of motor neuron disease. So John’s now 18 months
further down in that journey, and I’ve now asked him to tell us something about his current predicament. John: What I’ve got now is
the breathing’s gotten worse. I’ve got weakness in my hands,
my arms and my legs. So basically I’m in a wheelchair most of the time. SC: John’s just told us he’s in a wheelchair most of the time. So what these two clips show is not just the devastating
consequence of the disease, but they also tell us something about the shocking pace of the disease, because in just 18 months, a fit adult man has been rendered wheelchair- and respirator-dependent. And let’s face it, John could be anybody’s father, brother or friend. So that’s what happens when the motor nerve dies. But what happens when that myelin cell dies? You get multiple sclerosis. So the scan on your left is an illustration of the brain, and it’s a map of the connections of the brain, and superimposed upon which are areas of damage. We call them lesions of demyelination. But they’re damage, and they’re white. So I know what you’re thinking here. You’re thinking, “My God, this bloke came up and said he’s going to talk about hope, and all he’s done is give a really rather bleak and depressing tale.” I’ve told you these diseases are terrible. They’re devastating, numbers are rising, the costs are ridiculous, and worst of all, we have no treatment. Where’s the hope? Well, you know what? I think there is hope. And there’s hope in this next section, of this brain section of somebody else with M.S., because what it illustrates is, amazingly, the brain can repair itself. It just doesn’t do it well enough. And so again, there are two
things I want to show you. First of all is the damage of this patient with M.S. And again, it’s another one of these white masses. But crucially, the area that’s ringed red highlights an area that is pale blue. But that area that is pale blue was once white. So it was damaged. It’s now repaired. Just to be clear: It’s not because of doctors. It’s in spite of doctors, not because of doctors. This is spontaneous repair. It’s amazing and it’s occurred because there are stem cells in the brain, even, which can enable new myelin, new insulation, to be laid down over the damaged nerves. And this observation is important for two reasons. The first is it challenges one of the orthodoxies that we learnt at medical school, or at least I did, admittedly last century, which is that the brain doesn’t repair itself, unlike, say, the bone or the liver. But actually it does, but it
just doesn’t do it well enough. And the second thing it does, and it gives us a very clear direction
of travel for new therapies — I mean, you don’t need to be a rocket scientist to know what to do here. You simply need to find ways of promoting the endogenous, spontaneous
repair that occurs anyway. So the question is, why, if we’ve known that for some time, as we have, why do we not have those treatments? And that in part reflects the complexity of drug development. Now, drug development you might think of as a rather expensive but risky bet, and the odds of this bet are roughly this: they’re 10,000 to one against, because you need to screen
about 10,000 compounds to find that one potential winner. And then you need to spend 15 years and spend over a billion dollars, and even then, you may not have a winner. So the question for us is, can you change the rules of the game and can you shorten the odds? And in order to do that, you have to think, where is the bottleneck in this drug discovery? And one of the bottlenecks is
early in drug discovery. All that screening occurs in animal models. But we know that the proper
study of mankind is man, to borrow from Alexander Pope. So the question is, can we study these diseases using human material? And of course, absolutely we can. We can use stem cells, and specifically we can use human stem cells. And human stem cells are these extraordinary but simple cells that can do two things: they can self-renew or make more of themselves, but they can also become specialized to make bone, liver or, crucially, nerve cells, maybe even the motor nerve cell or the myelin cell. And the challenge has long been, can we harness the power, the undoubted power of these stem cells in order to realize their promise for regenerative neurology? And I think we can now, and the reason we can is because there have been
several major discoveries in the last 10, 20 years. One of them was here in Edinburgh, and it must be the only celebrity sheep, Dolly. So Dolly was made in Edinburgh, and Dolly was an example of the first cloning of a mammal from an adult cell. But I think the even more significant breakthrough for the purposes of our discussion today was made in 2006 by a Japanese scientist called Yamanaka. And what Yamaka did, in a fantastic form of scientific cookery, was he showed that four ingredients, just four ingredients, could effectively convert any cell, adult cell, into a master stem cell. And the significance of this is difficult to exaggerate, because what it means that
from anybody in this room, but particularly patients, you could now generate a bespoke, personalized tissue repair kit. Take a skin cell, make it a master pluripotent cell, so you could then make those cells that are relevant to their disease, both to study but potentially to treat. Now, the idea of that at medical school — this is a recurring theme, isn’t
it, me and medical school? — would have been ridiculous, but it’s an absolute reality today. And I see this as the cornerstone of regeneration, repair and hope. And whilst we’re on the theme of hope, for those of you who might have failed at school, there’s hope for you as well, because this is the school report of John Gerdon. [“I believe he has ideas about becoming a scientist;
on his present showing this is quite ridiculous.”] So they didn’t think much of him then. But what you may not know is that he
got the Nobel Prize for medicine just three months ago. So to return to the original problem, what is the opportunity of these stem cells, or this disruptive technology, for repairing the damaged brain, which we call regenerative neurology? I think there are two ways you can think about this: as a fantastic 21st-century drug discovery tool, and/or as a form of therapy. So I want to tell you a little bit about both of those in the next few moments. Drug discovery in a dish is how people often talk about this. It’s very simple: You take a patient with a disease, let’s say motor neuron disease, you take a skin sample, you do the pluripotent reprogramming, as I’ve already told you, and you generate live motor nerve cells. That’s straightforward, because that’s what pluripotent cells can do. But crucially, you can then compare their behavior to their equivalent but healthy counterparts, ideally from an unaffected relative. That way, you’re matching for genetic variation. And that’s exactly what we did here. This was a collaboration with colleagues: in London, Chris Shaw; in the U.S.,
Steve Finkbeiner and Tom Maniatis. And what you’re looking at, and this is amazing, these are living, growing, motor nerve cells from a patient with motor neuron disease. It happens to be an inherited form. I mean, just imagine that. This would have been unimaginable 10 years ago. So apart from seeing them
grow and put out processes, we can also engineer them so that they fluoresce, but crucially, we can then
track their individual health and compare the diseased motor nerve cells to the healthy ones. And when you do all that and put it together, you realize that the diseased ones, which is represented in the red line, are two and a half times more likely to die than the healthy counterpart. And the crucial point about this is that you then have a fantastic assay to discover drugs, because what would you ask of the drugs, and you could do this through a high-throughput automated screening system, you’d ask the drugs, give me one thing: find me a drug that will bring the red line closer to the blue line, because that drug will be a high-value candidate that you could probably take direct to human trial and almost bypass that bottleneck that I’ve told you about in drug discovery with the animal models, if that makes sense. It’s fantastic. But I want to come back to how you might use stem cells directly to repair damage. And again there are two ways to think about this, and they’re not mutually exclusive. The first, and I think in the long run the one that will give us the biggest dividend, but it’s not thought of that way just yet, is to think about those stem cells that are already in your brain, and I’ve told you that. All of us have stem cells in the brain, even the diseased brain, and surely the smart way forward is to find ways that you can promote and activate those stem cells in your brain already to react and respond appropriately to damage to repair it. That will be the future. There will be drugs that will do that. But the other way is to effectively parachute in cells, transplant them in, to replace dying or lost cells, even in the brain. And I want to tell you now an experiment, it’s a clinical trial that we did, which recently completed, which is with colleagues in UCL, David Miller in particular. So this study was very simple. We took patients with multiple sclerosis and asked a simple question: Would stem cells from the bone marrow be protective of their nerves? So what we did was we took this bone marrow, grew up the stem cells in the lab, and then injected them back into the vein. I’m making this sound really simple. It took five years off a lot of people, okay? And it put gray hair on me and caused all kinds of issues. But conceptually, it’s essentially simple. So we’ve given them into the vein, right? So in order to measure whether
this was successful or not, we measured the optic nerve as our outcome measure. And that’s a good thing to measure in M.S., because patients with M.S. sadly suffer with problems with vision — loss of vision, unclear vision. And so we measured the size of the optic nerve using the scans with David Miller three times — 12 months, six months, and before the infusion — and you can see the gently declining red line. And that’s telling you that
the optic nerve is shrinking, which makes sense, because their nerves are dying. We then gave the stem cell infusion and repeated the measurement twice — three months and six months — and to our surprise, almost, the line’s gone up. That suggests that the intervention has been protective. I don’t think myself that what’s happened is that those stem cells have made new myelin or new nerves. What I think they’ve done is they’ve promoted the endogenous stem cells, or precursor cells, to do their job, wake up, lay down new myelin. So this is a proof of concept. I’m very excited about that. So I just want to end with the theme I began on, which was regeneration and hope. So here I’ve asked John what his hopes are for the future. John: I would hope that sometime in the future through the research that you people are doing, we can come up with a cure so that people like me can lead a normal life. SC: I mean, that speaks volumes. But I’d like to close by first of all thanking John — thanking John for allowing me to share his insights and these clips with you all. But I’d also like to add to John and to others that my own view is, I’m hopeful for the future. I do believe that the disruptive technologies like stem cells that I’ve tried to explain to you do offer very real hope. And I do think that the day that we might be able to repair the damaged brain is sooner than we think. Thank you. (Applause)


99 Responses

  1. Prem Suraj

    March 3, 2014 2:34 pm

    A person who is very close to me suffers multiple sclerosis, I'm hopeful this research will provide them with a cure..

  2. Stu VS

    March 11, 2014 12:38 pm

    He's on the right track, clearly. The part that his talk doesn't address is the state of the body, specifically the gut. Notice how unhealthy his subject looked, distended belly drooping skin. The gut is ill. This is the body's defense system and early brain. It must be supported by probiotics and pure water. Then the rest of the body can work on healing itself. When the brain is fed healthy, oxygenated blood and hydrated, conductivity is optimized.

  3. Doctor BrainTaser

    March 14, 2014 6:45 pm

    I wonder why these abnormalities such as Parkinson's and Alzheimer's disease seem to present themselves in areas of increased substantia nigra, and what would be the practical results of regenerating lost neurons from these areas using the fruits of this research…nice! Keep it up! Try to gather as much support as possible in order to raise the masses' awareness towards this branch of science.

  4. ShatterGlassProject

    March 15, 2014 5:14 am

    In 2010, I was diagnosed with Ataxia and since then, I've been saying the same thing he is now, but without much scientific knowledge to back up my claims. I am very glad this man can better explain this.

  5. Faz A

    March 18, 2014 5:15 pm

    Excellent view from one window.
    "In spite of doctors" – truest words spoken. More of John's history: Drugs, exposure to environmental chemical, toxins, EMF = Epigenetics?
    Causation & Prevention? AGE most probably a confound. Exogenous Stem cells will succumb to conditions within body.
    Meanwhile, Breathe, learn & eat pure quality coconut oil.
    Anybody dying from Age per se or "natural causes" recently?
    See Dr Terry Wahls for dietary reversal of MS.

  6. CheddarBob39

    March 20, 2014 2:09 am

    Well this is good news for me. I just read on CNN that sleep deprivation can cause brain damage.  And I used to be quite an insomniac.  

  7. Berkay Karahacıoğlu

    March 22, 2014 5:38 pm

    one of the things I dont like about TED talks ( as a whole they are great but there a few things that should be improved) is they dont give any references or further reading/watching… if they do, it would be great…

  8. Sam M

    March 30, 2014 9:14 am

    Wow I just took an exam on this, and my textbook included regeneration of the brain! Amongst other things too.. How interesting

  9. CryptoTraders Bitcoin

    April 19, 2014 9:00 pm

    Binaural Beats can be a good guide for the brain to heal very specific areas. Sadly it's hard to prove and science takes years to research and adopt this strong healingtool. 

  10. Joell Photos

    July 22, 2014 10:24 pm

    If you ever had damage – well I should say injury you would know if it could repair. The Nueropathic pain I go through on a daily basis sometimes lets me believe YES our Brain can repair itself.

  11. Mind Agilis

    August 20, 2014 11:29 pm

    What can we do to improve cognitive performance/ stave off age-related cognitive decline? Could certain video games stimulate and strengthen brain functions such as (working) memory, attention, visuo-spatial acuity, mental flexibility, and even creativity?

  12. Ann Velopolcek

    August 16, 2015 6:08 pm

    After a recent shunt replacement surgery my son suffered a massive staph infection of the brain. The outcome is loss of surface sensation on the right side and severe balance problems as well as double vision. he is in physical rehab and making progress slowly. any suggestions ?

  13. earFront

    January 7, 2016 5:44 pm

    Promises, promises, My brain is broken now! How is this going to help me in the next year! Nothing presented here, accelerates the possibility for my TBI situation to become less intrusive to my present life.
    I get that in the future, there may be some better options for some folks, but for me now, this is just a bunch of fluff de$igned to $ell $eat$ in the "TED" corporation's bum holding place.
    I feel this "talk" presents me, with nothing more than a bunch of empty promises.

  14. 羅積康

    February 10, 2016 1:36 pm

    This is stupid idea. God prepare more than enough adult stem cells in every part of human body. How to trigger those adult stem cells, in situ, to differentiate into specified cells for repairement of damaged tissue and organ is real stem cell therapy. Global research of stem cell therapy is completely wrong. Nano-medication, based on God formed man out of dirt from the ground and blew into his nostrils the breath of life, is the only true stem cell therapy. Nano-medication can breach bbb (blood-brain barrier) as well as bcsfb (blood-cerebrospinal fluid barrier). Hence, to treat dementia should count on God's mercy, nano-medication only.
    Do you think stage 5 Parkinson's Disease can be reversed by nano-medication treatment, i.e. new dopaminergic neurons as well as Hcrt (hypocretin) neurons regenerated due to adult stem cells, inside of brain, differentiated and proliferated.

    Can nano-medication effectively treat osteonecrosis, cirrhosis, brain tumour, cerebral stroke, Parkinson's disease, etc. already?

    We humans are not God. Don't try to act like God.

    God bless!

  15. 羅積康

    February 10, 2016 1:36 pm

    Nano-medication is based on:

    God formed man out of dirt from the ground and blew into his nostrils the breath of life.

    During past five decades, U.S.A., Russia, France, Germany have made great efforts to unravel
    nano-medication unsuccessfully. God let me know HIS GREATEST MERCY to humans.

    Nano-medication can breach:

    a. bbb (blood-brain barrier)
    b. bcsfb (blood-cerebrospinal fluid barrier)

    Besides, correct stem cell therapy should be to trigger 'adult stem cells' IN SITU for differentiaton
    so as to repair damaged tissue and organ. Alas, global research of stem cell therapy is completely

    To effectively treat fifth grade of PD patient is:

    a. dopamine neurons

    b. Hcrt neurons

    should be regenerated through triggering of adult stem cells (inside of brain) IN SITU.

    According to my human experience, to apply nano-medication for fifth grade of PD patient, aged 85,
    can induce adult stem cells for dopamine neurons within one week. Of course, Hcrt neurons are
    at hypothalamus. It takes a little time more th replenish dead Hcrt neurons.

    Nano-meidcation should be the last-ditch treatment for PD, dementia and other brain diseases.

    God bless!

    David Lo

  16. Fernando Morales

    September 26, 2016 1:14 am

    To all of you who are suffering or have a significant other suffering from these chronic neurological diseases PLEASE read the work of Dr. David Perlmutter, you will be amazed at the cause of all these no-cure diseases.

  17. Janine Regan-Sinclair

    October 18, 2016 7:35 pm

    These audios help with Brain Training and clear trauma memories, help with concussion and head injuries.

  18. VJMV HVJ

    December 24, 2016 9:56 am

    There is a cure for spinal cord and possibly even brain nerve injuries.

    Spinal cord and brain nerve injuries can be cured using technology that works using magnetic fields in a medical environment.
    You can use magnetic fields to target dormant nerve cells inside the spinal cord and possibly even inside the brain. Magnetic fields can stimulate (ex. turn on) dormant nerve cells. Once the nerve cells are turned on they can begin multiply and repair damaged nerve tissue just like ordinary nerve cells in the peripheral system (ex. nerves that are outside the brain and spinal cord).

    Peripheral nerves (which are nerves outside the brain and spinal cord) have the ability to heal and repair. For example, if you injure your leg and damage a nerve the damaged nerve in your leg can be repaired/heal after a couple of months. This damaged nerve can heal/repair….because it is a nerve that is not in the brain or spinal cord. Nerves/nerve tissue that is not in the brain or spinal cord (ex. nerves in your arms, leg, chest, …etc) can heal if they are damaged.

    Magnetic fields, used for medical purposes, must be “tuned in” to the proper frequency at which the nerve cells inside the brain or spinal cord are operating at. This means that the magnetic fields must be properly calibrated and prepared for each individual patient so that the nerve cells inside that specific patient can become excited/stimulated and thus multiply and heal damaged nerves. This is kind of like ultrasound where the technician uses different types of sound to make different pictures of the inside of the body except here a doctor is using/selecting different types of (magnetic) energy to stimulate/excite (ex. turn on) dormant nerve cells inside the damaged parts of the spinal cord and perhaps the brain as well.

    One very positive advantage to using this type of technology is that there is no ionizing radiation exposure to the patient. This means that magnetic field does not pose a health risk (there is no damaging radiation) to the patient. So a patient can be treated many times (ex. do magnetic field treatment 20 times) and have zero radiation.

    This type of technology (using magnetic fields) to treat damaged nerves must be used with caution, carefully, when treating damaged nerves inside the brain. You need to take extra caution when treating nerve tissue inside the brain because the brain has many functions and many processes, and in general it is a very complex organ.

  19. ॐ Jordan Gould

    January 16, 2017 3:12 pm

    I recently suffered a drug overdose and my brain has not been the same since. I have been having trouble remembering things, articulating sentences and feeling more depression and anxiety than usual. I hope that neurogenesis and neuroplasticity will help me to go back to the way I was before.

  20. Doug Mcwilliams

    February 1, 2017 4:00 am

    cures are coming at a rapid pace. We can reverse brain damage and reverse the effects of aging. Diet, exercise, and MINDSET are key. Our attitude shapes everything. never give up hope, there are cures around the corner

  21. Adriana Flores

    April 6, 2017 6:14 am

    I am a victim of voice to skull for two years here in the Bay Area, I am not taking medicine because I know that medicine cannot stop the voices that are done by a Brazilian mafia Goiania. I had talked to six psychiatrist and I disagree with their thoughts about the difference of voice to skull and some kind of mental illness. I my case I am 100% sure that ounce I meet the Brazilian group face-to-face and their don't open their mouth I will not listen to them. They are real people behind the voices I am listening. I am here to ask for help of someone that can help me recover my short memory that has been affect by the electronic neural monitoring device that they use to hit my brain. In the beginning I forgot everything even the name of people that I knew before and the address that I lived a month before I started listening to this Brazilian harassers. I am recovering my brain with foods that I believe it helps. And I am seeing results, but it not the same way that it used to be. My ability to learn a new language has been dramatically hurt. The Brazilians are telling me that what they are doing to me has messed up my brain and body for the rest of my life. I have noticed that my health has been affected by that electronic harassment.

  22. Brad Berry

    April 19, 2017 1:05 pm

    I have sustained a TBI and I have, fortunately pretty much recovered, my one piece of advice, that I've come across, is to constantly expand your mind with knowledge.

  23. Hairy Chinese Kid

    April 22, 2017 7:46 pm

    Age related diseases because the longer you live the more time there is for heavy metals to build up in the body. Mercury has over a 20 year half life in the brain unless it is chelated out

  24. Giannis GALANOPOULOS

    April 24, 2017 11:28 pm

    in 10 years or more maybe this might be a reality but it will cost at least 70k or more dollars per
    'surgery'' if you consider that the annual cost of the latest ms drug-crap is 65k dollars…someday we will able to cure these horrible diseases using this wonderful way but only when medical mafia is sure that will has the same profits as now


    June 2, 2017 10:44 am

    I got a nice laugh since I'm both a rocket scientist and a person with brain trauma. On most days I cry but got some humor this morning… I write quantum theorems on reverse gravitation yet since my car accident I sometimes have no idea where I'm at when I get out of the grocery store. It's interesting. But I have faith in my brain's ability to come back better than ever with my daily meditation practice, delicious organic nutrition, and my amazing therapists at Boulder Brain Recovery. 😎💛

  26. Andreas Georgiou

    June 6, 2017 12:26 pm

    Please, if anybody has any info on where I could get stem cell treatment for my father please get in touch with me. We are UK based and are unable to travel with him in his current state

  27. mr C

    July 23, 2017 6:28 pm

    i dont think jon was fit he was overweight and im sure that definitely impacts breathing as well.

  28. R P Singh

    November 3, 2017 3:31 am

    Acupressure , Yoga Reiki and Healing Therapy good for health.
    We cure many more deassis by Acupressure and Chakra Healer Therapy.
    Mine WhatsApp number

  29. Flower Sunflower

    February 2, 2018 5:12 pm

    Any contact to this professor please .
    My son 14 years old was born with hypoxia. I need consultation about stem cell. I hope it's can help him .

  30. How mathematicians create maths

    February 28, 2018 11:26 pm

    Hey people, hey Experts. I have a question for you. Do you think this means, that when researchers can do this… that there is Hope for curing mental Retardation as well? (Like some mental skills only very purely developed, etc)

  31. Camelia Hudson

    April 23, 2018 8:06 am

    Where about can we go for this type of therapy please? And what is the progress these days, after 4 years from your article?

  32. C Miller

    May 30, 2018 4:18 pm

    We have known about stem cells and their abilities for over a decade now and yet the government still keeps doctors in the US from utilizing this amazing treatment big Pharma does not want a cure

  33. carl young

    July 10, 2018 4:12 am

    maybe what he said in the start is the remedy.the brain and body must have electrical energy to work rite.there are things that can put this energy into the body and brain like a device called the violet ray that uses a telsla coil or the things you can buy now for depression that you put on your head that produce a current.

  34. Iris Børsheim Wang

    August 26, 2018 4:28 pm

    i have an scar that cases me to have sizures. Diagnose Epilepsy, It hurts no have sezurs and my arm itches for the inside. So hoping Stemrenu will make me better. Im happy too hear what u have u say about this?

  35. Dattatray Koli

    August 29, 2018 5:18 pm

    sir plz help us my son he admitted in sparsh hospital treatment going on brain dead if u have any help us he is 13 years old

  36. JMichael Drollinger

    October 1, 2018 1:30 am

    The question is not whether or not we CAN, but will we? The drug companies are not in the business of making us well…they are In the business of keeping us sick! So, I am expecting stem cells to go on the chopping block, and eventually be rejected by medical sciences.

  37. Srikanth Vhm

    October 27, 2018 3:47 am

    Hi sir, very hopful speach, i had a brain stroke last year, and i am suffering left side paralisis, can you please help me out, i want to get back to my normal life, i am from india, i am ready to come where ever you suggest me to come for treatment

  38. Vedika yadav

    November 19, 2018 7:15 pm

    Sir please help on Nearly two month ago my mother had been bite by a snake ,the snake was krait (indian) thenPrimary district also happened. But when doctor gives her vaxin she got nervous and she become cardiect arest then heart stopped no any movement in body since 2 hours. After 2 hours when she came to sense she forget all things about she about our family then after some time Slowly began to recognize abut us but not all thing we do MRI then dr says Brain cell and memory cells massenger cells are damage and there is no any treatment she suggested medicine and told that if medicine recovered some damage so okay with it and continue medicine but before she was behaved like crazy one thing which work she do repeted again and again her hand was trembling then afer medicine after few days hand trembling stopped but her eye was not okay she saw strenge way then afer she shake her head and shoulder we very worry about our mother dr says there is no any treatment it will grow with age to please suggest what we should do please

  39. naduyn

    December 19, 2018 7:17 am

    The one potential winner was discovered in 1935. Megadosing on vitamin C will reverse major diseases whatever it may be.

  40. Moonglow

    December 29, 2018 9:15 am

    My brain was destroyed by the drug "Clozapin". 4 years 100 mg/day. I had to withdraw cold turkey, barely survived with brain damage. 10 years later I'm still hearing voices. The doctor who precsribed this drug to me for social anxiety is now chief doctor in a different hospital.

  41. wienerdogman paul

    January 7, 2019 3:05 pm

    Love Ted talks 😀. This one is really interesting. The brain is amazing.

    Some I've seen make me wonder how they were approved to do one. What are the qualifications for someone to do a TED talk? I don't want to mention any specific talks to put them down publicly. I'm sure many would agree that not all talks are equal in credibility. I am therefore genuinely curious as to their acceptance process and overall intention with the Talks.
    Thank you

  42. Seb PT

    January 22, 2019 8:01 am

    Why promote the development of drugs when is possible use the frequencies? Prof. Keshe synchronised the body of a woman with cancer at the same frequency of the earth, obtaining a reset of the body with consequent cancer's regression. As dott. Siddharthan said, the brain is simple. And so are the solutions!!!

  43. Shaktivel Murugan Subramaniam

    March 5, 2019 4:59 pm

    Siddharthan Chandran, what is the end result of your research on " Can the damaged brain repair itself" ? B'cos I'm a stroke patient since 3 yrs. Love to hear from you. My no. +91 7448363633

  44. Rachael Alice

    March 28, 2019 8:23 pm

    Add to it all the people whose brains are being destroyed by Electro Shock given by psycharitists. Many patients lose their memories and some even lose their personality.

  45. JMichael Drollinger

    April 12, 2019 9:27 pm

    There's no hope for patients in the United States! The FDA is in bed with big pharma. They won't let a cure exist!

  46. lassus prophetam

    May 2, 2019 1:58 pm

    I am so glad this is not my doctor because if this is how his patients degress then he should not be a doctor

  47. Noname Account

    June 3, 2019 5:51 pm

    You dont need drugs. Take the following supplements to boost neurogenesis:
    Omega 3
    Krill oil
    Blueberry extract
    Green tea extract
    Ginkgo biloba extract
    Vitamine b12
    Vitamine e

  48. Bharat - Phir Banega Sone ki Cheediya

    June 7, 2019 5:25 pm


  49. Cullen Hart

    July 4, 2019 3:33 pm

    At 9 months old I crawled off a 12ft balcony onto rocks below. Severe TBI. Fracturing. Im mostly normal but my memory struggles big time and at age 37 my mental capabilities are seemingly diminishing.

  50. Healthy News Hub

    July 30, 2019 7:39 am

    Nice video Dr C. When we are born we do not come with a set of instructions how to heal our-self the body knows best but we interfere with it and nature to much.
    Dolly the sheep got her name dolly as the stem cells were from breast tissue and as dolly parton was well known for her breasts so they called the sheep dolly.

  51. Paramjit Gill

    August 4, 2019 1:52 pm

    One of the best talks I have heard and I do congratulate on your articulation on the subject. Your speech points to you being a Malaysian or a Singaporen and Kudos to that


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